Thermo Fisher Scientific CD28 Monoclonal Antibody (CC220)

Applications

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent

Functional Assay (Functional)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

Mouse anti-Bovine CD28, clone CC220 recognizes the bovine homologue of human CD28, a co-stimulatory cell surface molecule expressed by T cell subsets.

Target Information

CD28 antigen is a 44 kDa disulfide-linked homodimeric T cell-specific surface glycoprotein. It belongs to the immunoglobulin superfamily and is constitutively expressed on most peripheral blood T lymphocytes. CD28 acts as a critical co-stimulatory receptor that provides the second activation signal to T cells by binding CD80 and CD86 on antigen-presenting cells. It prevents T cells from entering an anergic or apoptotic state. In murine lymphoid organs and blood, all CD4+ and CD8+ T cells express CD28, with varying expression levels depending on maturation stage. CD28 dysfunction is associated with diseases such as mycosis fungoides and Sezary’s Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.