Thermo Fisher Scientific PDE4B Polyclonal Antibody, FITC
PDE4B 단백질을 인식하는 FITC 결합 토끼 폴리클로날 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. 인간, 마우스, 랫트 반응성. Affinity chromatography로 정제되었으며, -20°C 암소 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide common to all PDE4B subtypes taken near C-terminal |
| Conjugate | FITC (Fluorescein) |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene belongs to the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides act as second messengers regulating various cellular responses to extracellular signals such as hormones, light, and neurotransmitters. PDE enzymes regulate cellular concentrations of cyclic nucleotides and thus play a key role in signal transduction. PDE4B specifically hydrolyzes cAMP, and altered activity has been linked to schizophrenia and bipolar affective disorder. Multiple splice variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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