Thermo Fisher Scientific DAZ1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human DAZ1.

Target Information

This gene is a member of the DAZ gene family and a candidate for the human Y-chromosomal azoospermia factor. Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable, and there are several variations in the sequence of the DAZ repeat. Each copy also contains a 10.8 kb region that may be amplified; this region includes five exons encoding an RNA recognition motif domain. This gene contains three copies of the 10.8 kb repeat. However, no transcripts containing three copies of the RRM domain have been described; thus, the RefSeq for this gene contains only two RRM domains.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.