Thermo Fisher Scientific Phospho-PTRF (Tyr156) Polyclonal Antibody
Phospho-PTRF (Tyr156) 폴리클로널 항체로 인간, 마우스, 원숭이, 랫트 시료에 반응. Western blot과 Immunocytochemistry에 적합. 인산화된 Tyr156 위치의 PTRF를 특이적으로 검출. 고순도 크로마토그래피 정제 및 안정한 PBS/glycerol 저장 조건 제공.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CAVIN1 (Accession Q6NZI2), corresponding to amino acid residues around phosphorylated Tyr156 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818508 |
Product Specific Information
Antibody detects endogenous levels of PTRF only when phosphorylated at Tyr156.
Target Information
The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3′ end of pre-rRNA transcripts, regulating rRNA transcription by promoting the dissociation of transcription complexes and the re-initiation of polymerase I on nascent rRNA transcripts.
PTRF also localizes to caveolae at the plasma membrane and plays a critical role in the formation of caveolae and the stabilization of caveolins, translocating from caveolae to the cytoplasm after insulin stimulation.
PTRF is thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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