Thermo Fisher Scientific NF2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunoprecipitation (IP)

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

• Positive Samples: A549, A431, HeLa, SKOV3, Mouse brain, Mouse kidney, Mouse heart, Rat brain
• Cellular Location: Cell projection, Cytoplasm, Cytoplasmic granule, Cytoplasmic side, Nucleus, Peripheral membrane protein, Cytoskeleton, Filopodium membrane, Perinuclear region, Ruffle membrane
• Immunogen Sequence:
  TKPTYPPMNP IPAPLPPDIP SFNLIGDSLS FDFKDTDMKR LSMEIEKEKV EYMEKSKHLQ EQLNELKTEI EALKLKERET ALDILHNENS DRGGSSKHNT

Target Information

NF2 encodes a protein, Merlin, that is similar to members of the ERM family, which link cytoskeletal components with membrane proteins. Merlin interacts with cell-surface proteins, cytoskeletal regulators, and ion transport regulators.
This gene is highly expressed during embryonic development and in adults is found in Schwann cells, meningeal cells, lens, and nerve.
Mutations in NF2 are associated with neurofibromatosis type II, characterized by nervous system and skin tumors and ocular abnormalities.
Two predominant isoforms and several minor isoforms are produced by alternatively spliced transcripts.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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