Thermo Fisher Scientific CD59/Complement Regulatory Protein/Protectin Monoclonal Antibody (MACIF, 629)
인간 CD59 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로, IHC, ICC/IF, Flow Cytometry에 사용 가능. 비결합형 액상 형태이며, Protein G로 정제됨. 보존제 무첨가, -20°C 또는 -80°C에서 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MACIF, 629 |
| Immunogen | Human K562 tumor cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature (RT).
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at RT for 20 min.
Target Information
CD59 (Protectin) is a small (18–20 kDa) GPI-anchored, ubiquitously expressed inhibitor of the membrane attack complex (MAC). It acts as a key regulator that protects autologous cells from complement cascade-mediated lysis. CD59 binds to complement C8 and/or C9 during MAC assembly, preventing the incorporation of multiple C9 molecules required for pore formation.
Additionally, CD59 functions as a low-affinity ligand for human CD2, contributing to T cell costimulation and lymphocyte signal transduction.
Mutations in CD59 can lead to CD59 deficiency, characterized by hemolytic anemia, thrombosis, and cerebral infarction. Multiple alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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