Thermo Fisher Scientific UFD1L Polyclonal Antibody
Thermo Fisher Scientific의 UFD1L Polyclonal Antibody는 인간 UFD1L 단백질을 인식하는 Rabbit IgG 항체로, Western blot 및 IHC(P)에서 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 연구용으로만 사용.
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- PA556427
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human UFD1L. Recombinant protein control fragment (Product #RP-95339) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649234 |
Product Specific Information
Immunogen sequence:
QVESVNLQVA TYSKFQPQSP DFLDITNPKA VLENALRNFA CLTTGDVIAI NYNEKIYELR VMETKPDKAV SIIECDMNVD FDAPLG
Highest antigen sequence identity:
- Mouse: 100%
- Rat: 100%
Target Information
Ubiquitin-mediated proteolysis requires the transfer of ubiquitin (Ub) to lysine groups on selected cellular proteins, which then promotes their degradation by the 26S proteasome. Ub-fusions are cleaved by Ub-specific processing proteases (UBps) or by the Ub-fusion degradation (UFD) pathway.
The UFD1 protein, first characterized in yeast S. cerevisiae, has a human homolog known as UFD1L. In vitro, UFD1 attenuates degradation of Ub-fusions containing amino acid substitutions at Gly76 by promoting selective multiubiquitination of the Ub chain.
Mutations in the UFD1 gene are associated with CATCH22 syndrome, characterized by cardiac defects, cleft palate, and hypocalcemia, suggesting a role in developmental processes.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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