Thermo Fisher Scientific ITPKB Polyclonal Antibody
Human ITPKB 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ITPKB. Recombinant protein control fragment (Product #RP-94308). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2642827 |
Product Specific Information
Immunogen sequence:
PDKPFLRKAC SPSNIPAVII TDMGTQEDGA LEETQGSPRG NLPLRKLSSS SASSTGFSSS YEDSEEDISS DPE
Ortholog identity:
- Mouse: 83%
- Rat: 82%
Target Information
Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) regulates intracellular calcium levels by releasing calcium from internal stores. Ins(1,4,5)P3 is phosphorylated by inositol 1,4,5-trisphosphate 3-kinase (IP3K) to form inositol 1,3,4,5-tetrakisphosphate (Ins(1,4,5)P4), which is thought to regulate calcium influx across the plasma membrane.
IP3K exists as three isoforms: IP3KA, IP3KB, and IP3KC.
- IP3KA: Expressed in rat brain and testis
- IP3KB: Expressed in lung, thymus, testis, brain, and heart
IP3K activity is stimulated by calmodulin and phosphorylation via cAMP-dependent protein kinase, protein kinase C, or calcium/calmodulin-dependent protein kinase II, mediating inositol phosphate signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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