Thermo Fisher Scientific KDELR2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total ERD22.

Target Information

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by continual retrieval from the cis-Golgi or a pre-Golgi compartment. Sorting of these proteins depends on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes and binds the tetrapeptide-containing protein, returning it to the ER.

In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. In humans, several homologs of the ERD2 gene form the KDEL receptor gene family. KDELR2 is the second identified member, encoding a protein 83% identical to KDELR1. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
[Provided by RefSeq, Jul 2008]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.