Thermo Fisher Scientific KDELR2 Polyclonal Antibody
KDELR2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat에 반응하며 1 mg/mL 농도의 액상 형태로 제공. ERD22 단백질의 내인성 수준을 검출하며, 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KDELR2 (Accession P33947), corresponding to amino acid residues G88–I138 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851018 |
Product Specific Information
Antibody detects endogenous levels of total ERD22.
Target Information
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by continual retrieval from the cis-Golgi or a pre-Golgi compartment. Sorting of these proteins depends on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes and binds the tetrapeptide-containing protein, returning it to the ER.
In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. In humans, several homologs of the ERD2 gene form the KDEL receptor gene family. KDELR2 is the second identified member, encoding a protein 83% identical to KDELR1. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
[Provided by RefSeq, Jul 2008]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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