Thermo Fisher Scientific MEK3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunoprecipitation (IP)

• Tested Dilution: 0.2–1 µL/mg of lysate

Product Specifications

Product Specific Information

• This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05–0.1%) to prevent contamination.
• This antibody has specificity for Human MEK3/MKK3.

Target Information

MAP2K3 (MEK3) is a dual-specificity protein kinase involved in cellular signal transduction pathways and necessary for glucose transporter expression. It phosphorylates and activates MAPK14/p38-MAPK. This kinase can be activated by insulin and is required for glucose transporter expression. Expression of the RAS oncogene leads to accumulation of the active form of this kinase, resulting in constitutive activation of MAPK14 and oncogenic transformation of primary cells. Inhibition of this kinase is implicated in the pathogenesis of Yersinia pseudotuberculosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported for MEK3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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