Thermo Fisher Scientific MELK/HPK38 Polyclonal Antibody
MELK/HPK38 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC, ICC/IF, ELISA 등 다양한 응용에 적합합니다. Human, Mouse, Rat에 반응하며, Protein A로 정제된 1 mg/mL 액상 형태입니다. 암 연구 및 세포주기 조절 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human MELK/HPK38, amino acids 101–250 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MELK (Maternal Embryonic Leucine Zipper Kinase) is a serine/threonine kinase related to the AMPK family, involved in cell cycle regulation. It is overexpressed in various cancers and considered a potential therapeutic target. MELK phosphorylates substrates such as BCL2L14, CDC25B, MAP3K5/ASK1, and ZNF622, acting as an activator of apoptosis and regulator of mitosis. It plays a crucial role in cell proliferation, neural progenitor development, and carcinogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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