Thermo Fisher Scientific IL5RA/CD125 Polyclonal Antibody
IL5RA/CD125 폴리클로날 항체로 인간, 마우스, 랫트 반응성. 다양한 응용 분야(WB, IHC, ICC, ELISA)에 사용 가능. KLH 접합 합성 펩타이드 면역원 기반. 고순도 Protein A 정제, 액상 형태로 보관. 연구용 전용 제품.
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Thermo Fisher Scientific IL5RA/CD125 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human IL-5R alpha, amino acids 11–110 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Interleukin 5 (IL-5) is a soluble T cell-derived factor, also known as T cell replacing factor (TRF), that induces B cell and eosinophil growth and differentiation. IL-5 exerts its biological activity through the IL-5 receptor (IL-5R), composed of two chains: an alpha chain that binds IL-5 with low affinity and a beta chain that, together with the alpha chain, forms the high-affinity receptor complex. The cytoplasmic domains of both chains are essential for signal transduction. The membrane-proximal proline-rich sequence of the IL-5Rα cytoplasmic domain is critical for IL-5-induced proliferation, nuclear proto-oncogene expression, and tyrosine phosphorylation of proteins such as JAK1 and JAK2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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