Thermo Fisher Scientific Apolipoprotein J Monoclonal Antibody (C1)
Apolipoprotein J 단백질을 인식하는 mouse monoclonal antibody(C1)로, Western blot, IHC, ICC 등 다양한 응용에 적합합니다. Rat 시료에 반응하며 Protein A/G로 정제된 액상형 항체입니다. PBS 및 50% glycerol buffer에 보관하며 -20°C에서 안정적으로 저장 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 5–20 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C1 |
| Immunogen | Recombinant protein Clusterin (Apolipoprotein J). Antigen corresponds to amino acid range 227–447 of the target protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899047 |
Target Information
Isoform 1 functions as an extracellular chaperone that prevents aggregation of nonnative proteins and stress-induced aggregation of plasma proteins. It inhibits amyloid fibril formation by several proteins (APP, APOC2, B2M, CALCA, CSN3, SNCA, LYZ variants) in vitro, maintaining them for refolding by other chaperones such as HSPA8/HSC70. It does not refold proteins directly but facilitates degradation or refolding pathways. Secreted isoforms protect cells from apoptosis and complement-mediated cytolysis, while intracellular forms regulate ubiquitination and proteasomal degradation, modulate NF-κB activity, and influence apoptosis and cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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