Thermo Fisher Scientific CCR2 Recombinant Rabbit Monoclonal Antibody (10L1L6)
CCR2 단백질을 인식하는 토끼 유래 재조합 단클론 항체로, Western blot과 ELISA에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며, 세포막 단백질 검출에 유용합니다. 고순도 친화 크로마토그래피 정제 및 안정한 글리세롤 기반 보존 용액 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:6,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 10L1L6 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–100 of human CCR2/CKR2 (P41597) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911921 |
Product Specific Information
- Positive test controls: A-549, U-937, Mouse lung, Rat lung
- Subcellular localization: Cell membrane, Multi-pass membrane protein
Immunogen sequence:
MLSTSRSRFI RNTNESGEEV TTFFDYDYGA PCHKFDVKQI GAQLLPPLYS LVFIFGFVGN MLVVLILINC KKLKCLTDIY LLNLAISDLL FLITLPLWAH
Target Information
CCR2 (C-C chemokine receptor type 2) is a chemokine receptor involved in the regulation of monocyte and macrophage trafficking. It is upregulated in response to inflammation and may influence resistance to HIV-1 infection or delayed progression to AIDS through polymorphisms. Its ligand, monocyte chemoattractant protein-1 (MCP-1), is produced by endothelial and smooth muscle cells, mediating monocyte infiltration in atherosclerosis and inflammatory disorders such as rheumatoid arthritis, alveolitis, and tumor infiltration.
Two isoforms of CCR2 exist due to alternative splicing. It is expressed in various tissues including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessels. Increased expression has been observed in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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