ELK Biotechnology CR1 rabbit pAb
CR1 rabbit pAb는 인간, 랫트, 마우스에 반응하는 다클론 항체로 WB와 ELISA에 적합합니다. 합성 펩타이드 면역원으로 제작되었으며, 고순도 IgG 형태로 1 mg/ml 농도를 제공합니다. -20°C에서 1년간 안정적으로 보관 가능하며, 세포막 단일 통과형 단백질을 인식합니다.
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제품명
CR1 rabbit pAb
적용 분야
- Western Blot (WB)
- ELISA
권장 희석 배율
- WB: 1:500–1:2000
- ELISA: 1:5000–1:20000
제품 정보
| 항목 | 내용 |
|---|---|
| Immunogen | Synthesized peptide derived from part region of human protein |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 224 kD |
| GeneID (Human) | 1378 |
| Human Swiss-Prot No | P17927 |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Rat; Mouse |
| Storage | -20°C / 1 year |
배경 (Background)
This gene is a member of the receptors of complement activation (RCA) family and is located in the cluster RCA region of chromosome 1.
The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells.
The Knops blood group system is a system of antigens located on this protein.
The protein mediates cellular binding to particles and immune complexes that have activated complement.
Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, and sarcoidosis.
Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria.
Alternate allele-specific splice variants are known.
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