ELK Biotechnology CLAP2 rabbit pAb

제품명

CLAP2 rabbit pAb

제품 개요

ELK Biotechnology에서 제공하는 CLAP2 rabbit polyclonal antibody로, 인간, 생쥐, 랫트에서 반응합니다. 세포골격 및 미세소관 관련 단백질 연구에 유용하며, WB 및 ELISA 분석에 적합합니다.

제품 사양

세포 내 위치 (Cellular Localization)

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, chromosome centromere, kinetochore, spindle, Golgi apparatus, trans-Golgi network, cell membrane, ruffle membrane.
Localizes to microtubule plus ends and centrosomes, kinetochores, mitotic spindle (PubMed:15631994, 16866869, 16914514).
In migrating cells, localizes to microtubule plus ends and lamella lattice; requires ERC1 and PHLDB2 (PubMed:16824950).

배경 정보 (Background)

• Function: Microtubule plus-end tracking protein that stabilizes dynamic microtubules and is essential for cell polarization during migration.
• Mechanism: Enhances rescue frequency of depolymerizing microtubules by cortical attachment via ERC1 and PHLDB2, regulated by PI3K signaling.
• Kinetochore Role: Stabilizes microtubules for bipolar chromosome alignment.
• Post-translational Modification (PTM): Phosphorylated by GSK3B, ATM, or ATR; phosphorylation may regulate microtubule binding.
• Similarity: Belongs to CLASP family; contains 5 HEAT repeats.
• Subunit Interaction: Interacts with CLIP2, ERC1, MAPRE1, MAPRE3, microtubules, PHLDB2, RSN.
• Tissue Specificity: Brain-specific.