ELK Biotechnology CLD12 rabbit pAb
CLD12 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간 및 생쥐 시료에 반응하며 세포막 및 타이트 정션 단백질 연구에 활용됩니다. -20°C에서 1년 보관 가능합니다.
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제품명
CLD12 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB, ELISA |
| Recommended Dilutions | WB: 1:500–1:2000 ELISA: 1:5000–1:20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 26 kD |
| Gene ID (Human) | 9069 |
| Human Swiss-Prot No. | P56749 |
| Cellular Localization | Cell junction, tight junction; Cell membrane; Multi-pass membrane protein |
| Species Reactivity | Human, Mouse |
Background
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transduction. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca²⁺ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.
(provided by RefSeq, Sep 2011)
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