ELK Biotechnology JAM3 rabbit pAb
JAM3 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 사용 가능. 인간, 마우스, 랫트 시료에 반응하며, 세포막 및 세포 접합부에서 발현되는 JAM3 단백질 검출에 적합. -20°C에서 1년 보관 가능.
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ELK Biotechnology JAM3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | JAM3 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 60–140) |
| Species Reactivity | Human; Mouse; Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 34 kD |
| Gene ID (Human) | 83700 |
| Human Swiss-Prot No. | Q9BX67 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Cell junctions (desmosome, tight junction). Detected in acrosome region of developing spermatids. Expressed at desmosomes in epithelial cells; localized to cell surface of endothelial cells and recruited to cell-cell contacts upon VEGF stimulation. Soluble form (JAM-C): Secreted. |
| Storage | -20°C, 1 year |
| Host | Rabbit |
Background
Tight junctions are one form of cell-to-cell adhesion in epithelial or endothelial sheets, forming continuous seals that act as barriers to solute and water diffusion through the paracellular space. The protein encoded by this immunoglobulin superfamily gene is localized in tight junctions between high endothelial cells. Unlike other family members, this protein does not adhere to leukocyte cell lines and only forms weak homotypic interactions. It belongs to the junctional adhesion molecule (JAM) family and acts as a receptor for another family member. Mutations in an intron of this gene are associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing generates multiple transcript variants.
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