ELK Biotechnology FAT1 rabbit pAb
FAT1 단백질을 인식하는 토끼 폴리클로날 항체로, IHC 및 IF 실험에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며 세포막 및 핵에서 발현되는 FAT1 단백질 검출에 활용됩니다. 농도 1 mg/ml, -20°C에서 1년 보관 가능합니다.
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FAT1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | FAT1 rabbit pAb |
| Applications | IHC; IF |
| Recommended Dilutions | IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 1140–1220) |
| Species Reactivity | Human; Rat; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 504 kD |
| GeneID (Human) | 2195 |
| Human Swiss-Prot No | Q14517 |
| Cellular Localization | [Protocadherin Fat 1]: Cell membrane; Single-pass type I membrane protein. [Protocadherin Fat 1, nuclear form]: Nucleus. |
| Storage | -20°C / 1 year |
| Host | Rabbit |
Background
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product belongs to the cadherin superfamily, a group of integral membrane proteins characterized by cadherin-type repeats.
It contains 34 tandem cadherin-type repeats, five EGF-like repeats, and one laminin A-G domain. The gene is highly expressed in several fetal epithelia, likely functioning as an adhesion molecule and/or signaling receptor involved in developmental processes and cell communication.
Transcript variants from alternative splicing or promoter usage exist but are not fully described. (RefSeq, Jul 2008)
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