ELK Biotechnology CRYAA rabbit pAb
CRYAA 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간, 마우스, 랫트에 반응하며, 세포질 및 핵에서 발현되는 단백질 검출에 유용합니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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ELK Biotechnology CRYAA rabbit pAb
제품 설명
CRYAA rabbit pAb는 인간 CRYAA 단백질의 1–80 아미노산 구간에서 합성된 펩타이드를 면역원으로 제작된 토끼 폴리클로날 항체입니다. 이 항체는 Western Blot(WB) 및 ELISA 분석에 적합하며, 인간, 마우스, 랫트 시료에서 반응합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | CRYAA rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 1–80) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 19 kDa |
| GeneID (Human) | 1409 |
| Human Swiss-Prot No. | P02489 |
| Cellular Localization | Cytoplasm, Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| Species Reactivity | Human; Mouse; Rat |
Background
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins consist of two gene products: alpha-A and alpha-B, corresponding to acidic and basic forms, respectively.
Alpha crystallins can be induced by heat shock and belong to the small heat shock protein (HSP20) family. They act as molecular chaperones, forming large soluble aggregates rather than renaturing proteins directly.
Post-translational modifications reduce their chaperone activity. These aggregates typically contain 30–40 subunits, with alpha-A and alpha-B in a 3:1 ratio.
Alpha crystallins also exhibit autokinase activity and contribute to intracellular architecture. The encoded protein is considered a moonlighting protein due to its multiple functional roles.
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