ELK Biotechnology COX3 rabbit pAb

COX3 rabbit pAb

제품 개요

COX3 rabbit pAb는 인간, 생쥐, 랫트 시료에서 COX3 단백질을 검출하기 위한 폴리클로날 항체입니다. Western blot(WB)과 ELISA 실험에 적합하며, 미토콘드리아 내막 단백질 연구에 유용합니다.

제품 정보

Background

Defects in mitochondrial genes such as MT-ATP6 and MT-CO3 are associated with several mitochondrial disorders, including:

• Infantile bilateral striatal necrosis (MIM:500003)
• Leber hereditary optic neuropathy (LHON, MIM:535000)
• Leigh syndrome (LS, MIM:256000)
• Neurogenic muscle weakness, ataxia, and retinitis pigmentosa (NARP, MIM:551500)
• Cytochrome c oxidase deficiency (COX deficiency, MIM:220110)
• Recurrent myoglobinuria (MIM:550500)
• Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS)

Function

Mitochondrial membrane ATP synthase (Complex V) produces ATP from ADP using a proton gradient generated by the respiratory chain.
F-type ATPases consist of two structural domains:

• F(1): Extramembranous catalytic core
• F(0): Membrane proton channel

ATP synthesis in the F(1) domain is coupled to proton translocation via a rotary mechanism of the central stalk subunits. Subunits I, II, and III form the functional core of the enzyme complex.

Similarity

• Belongs to the ATPase A chain family
• Belongs to the ATPase protein 8 family
• Belongs to the cytochrome c oxidase subunit 3 family

Subunit Structure

F-type ATPases have two main components:

• CF(1): Catalytic core (subunits α₃, β₃, γ₁, δ₁, ε₁)
• CF(0): Membrane proton channel (subunits a, b, c)

제품 이미지

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