Thermo Fisher Scientific TRPC6 Polyclonal Antibody
TRPC6 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB, IHC, ICC/IF에 사용 가능. 인간 및 마우스 반응성, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 제공되며, 2–8°C 보관 권장.
- 카탈로그번호
- PA520257
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1 µg/mL |
| Immunohistochemistry (IHC) | 10 µg/mL |
| Immunocytochemistry (ICC/IF) | 2–5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide from near the amino terminus of human TRPC6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154301 |
Product Specific Information
- Suggested positive control: K562 cell lysate
- PA5-20257 can be used with blocking peptide PEP-0393
Target Information
Trpc6 forms a receptor-activated calcium channel in the cell membrane. The Trpc6 channel is activated by diacylglycerol (DAG) and is thought to be controlled by a phosphatidylinositol second messenger system. Activation occurs independently of protein kinase C and is not triggered by low intracellular calcium levels.
Defects in the Trpc6 gene cause focal segmental glomerulosclerosis 2 (FSGS2).
Trpc6 belongs to the mammalian transient receptor potential (TRP) superfamily, specifically the “canonical TRP” (TRPC) family. Members of this family are activated through PLC-coupled receptors and function as receptor-regulated cation channels.
The TRPC3/6/7 subfamily can be activated by DAG analogs, suggesting a mechanism of activation by PLC-coupled receptors. When expressed in transfected cells, Trpc6 acts as a non-selective, store-independent, receptor-activated cation channel, insensitive to IP3 activation and PKC-independent.
Diseases associated with TRPC6 include Glomerulosclerosis, Focal Segmental, 2 and Focal Segmental Glomerulosclerosis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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