Thermo Fisher Scientific FBXW7 Monoclonal Antibody (OTI6F5)

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunohistochemistry (IHC)

• Tested Dilution: Not specified
• View 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Target Information

F-Box and WD Repeat Domain Containing 7 (FBXW7) is a member of the F-box protein family, characterized by an approximately 40 amino acid motif known as the F-box. These proteins form part of the SCF ubiquitin ligase complex (SKP1-cullin-F-box), which functions in phosphorylation-dependent ubiquitination.

F-box proteins are divided into three classes:

• Fbws containing WD-40 domains
• Fbls containing leucine-rich repeats
• Fbxs containing other protein-protein interaction modules or no recognizable motifs

FBXW7 belongs to the Fbws class, containing an F-box and seven tandem WD40 repeats. It binds directly to cyclin E and may target cyclin E for ubiquitin-mediated degradation. Mutations in this gene have been found in ovarian and breast cancer cell lines, suggesting a role in cancer pathogenesis. Multiple transcript variants encoding different isoforms exist for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.