Thermo Fisher Scientific MMP19 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: human synovial fluid, MMP19-transfected 293T
• Predicted reactivity: Rat (81%), Bovine (85%)
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

MMP-19 (also known as RASI-1 or MMP-18) is a 508 amino acid peptide originally isolated as an autoantigen from the synovium of a rheumatoid arthritis (RA) patient. It is expressed on activated PBMCs, TH1 lymphocytes, and Jurkat T lymphoma cells, suggesting a role in RA-associated joint tissue destruction.
MMP-19 is present in the smooth muscle cells of large blood vessels but not in endothelial cells. Inflamed synovial capillaries strongly express MMP-19 in the cytoplasm, and its induction in endothelial cells during acute inflammation suggests involvement in angiogenesis.
MMP-19 mRNA (2.7 kb) is expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis, colon, and heart.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.