Thermo Fisher Scientific MMP19 Polyclonal Antibody
Thermo Fisher Scientific의 MMP19 Polyclonal Antibody는 인간 MMP19 단백질을 인식하는 토끼 IgG 항체로, Western blot 및 IHC(P)에서 사용 가능합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/BSA/glycerol buffer에 보관됩니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 210–508 of MMP19 (Uniprot ID: Q99542) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2552100 |
Product Specific Information
- Recommended positive controls: human synovial fluid, MMP19-transfected 293T
- Predicted reactivity: Rat (81%), Bovine (85%)
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
MMP-19 (also known as RASI-1 or MMP-18) is a 508 amino acid peptide originally isolated as an autoantigen from the synovium of a rheumatoid arthritis (RA) patient. It is expressed on activated PBMCs, TH1 lymphocytes, and Jurkat T lymphoma cells, suggesting a role in RA-associated joint tissue destruction.
MMP-19 is present in the smooth muscle cells of large blood vessels but not in endothelial cells. Inflamed synovial capillaries strongly express MMP-19 in the cytoplasm, and its induction in endothelial cells during acute inflammation suggests involvement in angiogenesis.
MMP-19 mRNA (2.7 kb) is expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis, colon, and heart.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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