Thermo Fisher Scientific SYNE3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 740-920 of human SYNE3 (NP_6898053) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SYNE3,uniProtId:Q6ZMZ3-1,ncbiNodeId:9606,antigenRange:740-920,antigenLength:975,antigenImageFileName:PA5-89105_SYNE3_Q6ZMZ3-1_Rabbit.svg,antigenImageFileNamePDP:PA5-89105_SYNE3_Q6ZMZ3-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.88 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805358

Product Specific Information

Immunogen sequence: LRLLEESLLS LIRNWHLQRM EVDSGKKMVF TNNIPKSGFL INPMDPIPRH RRRANLLQEE EGSHEDFSQL LRNFGQWLQV ENSKLVRIIA MRTSTAEDLR TRKSKLQELE ARVPEGQHLF ENLLRLGPAR GTSDELEDLR YQWMLYKSKL KDSGHLLTQS SPGEPTGFQK TRRWRGLGSL F; Positive Samples: Jurkat, K-562, LO2, HepG2; Cellular Location: Nucleus envelope, Nucleus outer membrane, Rough endoplasmic reticulum, Single-pass type IV membrane protein

Target Information

As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells. [UniProt]

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.