Thermo Fisher Scientific CDKL2 Monoclonal Antibody (OTI10H3), TrueMAB
CDKL2 단백질을 인식하는 Mouse IgG2b 단일클론 항체로 Western blot에 최적화됨. Human 시료에 반응하며, 정제된 액상 형태로 제공. PBS, BSA, glycerol 기반 버퍼에 보존되어 안정적이며 연구용으로 적합.
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Applications
- Western Blot (WB): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI10H3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 291–493 of human CDKL2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The activation of signal transduction pathways by growth factors, hormones, and neurotransmitters is mediated by the MAP kinases ERK1 and ERK2. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites within a characteristic Thr-Glu-Tyr motif. The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group of proteins and is closely related to p42 KKIALRE. KKIAMRE is predominantly expressed in testis, kidney, brain, and lung. It contains the conserved MAP kinase dual phosphorylation motif Thr-Asp-Tyr and is activated by EGF treatment. Unlike other MAP kinases, its EGF-stimulated kinase activity does not require phosphorylation of this motif.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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