Thermo Fisher Scientific AMID Polyclonal Antibody
Thermo Fisher Scientific의 AMID Polyclonal Antibody는 인간, 마우스, 랫트 시료에서 AIFM2 단백질을 검출하는 토끼 IgG 기반 항체입니다. Western blot, IHC, ICC/IF에 적합하며, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human AIFM2 (Accession Q9BRQ8), amino acid residues M91–R141 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852551 |
Product Specific Information
This antibody detects endogenous levels of total AIFM2.
Target Information
The p53 tumor suppressor protein induces cell cycle arrest or apoptosis in response to cellular stresses. PRG3 (p53-responsive gene 3) is specifically induced under p53-dependent apoptotic conditions in human colon cancer cells. PRG3 shows significant homology to bacterial oxidoreductases and apoptosis-inducing factor (AIF). Unlike AIF, PRG3 localizes in the cytoplasm and its ectopic expression induces apoptosis. Thus, PRG3 is identified as a novel p53 target gene involved in a p53-dependent apoptosis pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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