Thermo Fisher Scientific PCDH12 Polyclonal Antibody
Rabbit polyclonal antibody against human PCDH12. Recognizes recombinant protein (aa 471–554). Suitable for research use in studying cell adhesion and vascular expression. Supplied as liquid, 0.2 mg/mL, store at 4°C short term or -20°C long term.
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Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PCDH12 (amino acids 471–554) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2645250 |
Product Specific Information
Immunogen sequence:
ENNLPSLHLI TIKAHDADLG INGKVSYRIQ DSPVAHLVAI DSNTGEVTAQ RSLNYEEMAG FEFQVIAEDS GQPMLASSVS VWVS
Highest antigen sequence identity to the following orthologs:
- Mouse: 85%
- Rat: 86%
Target Information
Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules.
Protocadherin 12 (PCDH12) was initially identified through PCR screening of mouse heart microvascular endothelial cell RNA.
Its mRNA is strongly expressed in highly vascularized organs such as lung and kidney, as well as in glycogen-rich trophoblasts in the placenta.
PCDH12 knockout mice are viable and fertile but show reduced placental and embryonic sizes compared to wild type.
Further studies revealed significant expression changes in over 2,000 genes, including those involved in:
- Tissue morphogenesis
- Angiogenesis
- Cell-matrix adhesion and migration
- Immune response
- Chromatin remodeling
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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