Thermo Fisher Scientific Estrogen Receptor, alpha (Marker of Estrogen Dependence) Monoclonal Antibody (rESR1/1935)
에스트로겐 수용체 알파(ERα)를 표적하는 단클론 항체로, 인간 시료에 반응합니다. Western blot 및 면역조직화학(IHC)에 적합하며, 단백질 A/G 정제 및 PBS 완충액에 보관됩니다. 연구용으로 에스트로겐 의존성 마커 분석에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | - |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rESR1/1935 |
| Immunogen | Recombinant full-length human Estrogen Receptor alpha protein (UniProt ID: P03372-1, amino acids 1–595) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen, undergoes a conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA. Through this mechanism, ER regulates gene transcription via coactivator or corepressor proteins.
There are two forms of the estrogen receptor, alpha (ESR1) and beta (ESR2), encoded by separate genes. Multiple isoforms of estrogen receptor-alpha exist due to alternative RNA splicing (Isoforms 1–4, ranging from 35–66 kDa). ERs are widely expressed in various tissues, playing critical roles in sexual development, reproductive function, and bone health. They are also implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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