Thermo Fisher Scientific Tankyrase Polyclonal Antibody
Tankyrase 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 Immunocytochemistry에 적합. 인간 유래 샘플에서 검증됨. Wnt 신호전달 및 텔로미어 조절 연구에 활용 가능. 액상 형태, 4°C 단기 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:250–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide made to a region of human Tankyrase within residues 250–350 (UniProt# O95271) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2287583 |
Product Specific Information
PA1-32225 detects Tankyrase from human samples.
Target Information
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length, and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379).
Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, two key components of the beta-catenin destruction complex. PARsylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation.
Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination.
Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length.
Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI.
May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.
May be involved in spindle pole assembly through PARsylation of NUMA1.
Stimulates 26S proteasome activity.
[Source: UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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