Thermo Fisher Scientific PPBP Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In direct ELISAs, approximately 15% cross-reactivity with recombinant human GRO beta is observed and 5% cross-reactivity with recombinant rat CINC-3 is observed.
• Reconstitute at 0.2 mg/mL in sterile PBS.
• Endotoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Target Information

Members of the α-chemokine subfamily of inducible, secreted, pro-inflammatory cytokines share a motif where the first two cysteine residues are separated by a single residue (Cys-X-Cys) and are chemotactic for neutrophils.
The platelet basic protein (PBP), part of the α-chemokine family, resides in the α-granules of platelets and is released upon activation. Proteolytic cleavage of the amino terminus of PBP generates several peptides, including mature PBP, connective tissue-activating peptide III (CTAP III, also known as low affinity platelet factor IV (LA-PF4)), β-thromboglobulin (β-TG), and neutrophil-activating peptide 2 (NAP-2).
PBP and its truncated derivatives mediate inflammation and wound healing. NAP-2 specifically activates chemotaxis and degranulation in neutrophils during inflammation. The gene encoding human PBP maps to chromosome 4q12–q13.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.