Thermo Fisher Scientific EpCAM/CD326 (Epithelial Marker) Recombinant Rabbit Monoclonal Antibody (EGP40/8130R)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 2 µg/mL

Immunohistochemistry (PFA fixed) (IHC (PFA))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Target Information

Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in epithelial cells with a molecular weight of approximately 40 kDa. It functions as a calcium-independent epithelial cell adhesion molecule and influences cell cycle, proliferation, and metabolism through induction of c-myc, cyclin A, and E. Ep-CAM-mediated adhesions negatively regulate cadherin-mediated adhesions, affecting epithelial differentiation and growth. Overexpression of Ep-CAM is associated with enhanced epithelial proliferation and is highly expressed in human carcinomas, serving as a marker for tumors of epithelial lineage. It is found on the basolateral surface of most simple epithelia and many carcinoma types and helps distinguish adenocarcinomas from pleural mesotheliomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지