Thermo Fisher Scientific EpCAM/CD326 (Epithelial Marker) Recombinant Rabbit Monoclonal Antibody (EGP40/8130R)
EpCAM/CD326 표지 항체로 인간 상피세포 및 암조직 연구에 적합. 재조합 토끼 단클론 항체로 높은 특이성과 재현성 제공. IHC(P) 및 IHC(PFA) 적용 가능. 단백질 A 정제, PBS 버퍼, 보존제 없음. -20°C 보관.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2 µg/mL
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | EGP40/8130R |
| Immunogen | Recombinant human EpCAM fragment from extracellular domain (around aa100–224) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in epithelial cells with a molecular weight of approximately 40 kDa. It functions as a calcium-independent epithelial cell adhesion molecule and influences cell cycle, proliferation, and metabolism through induction of c-myc, cyclin A, and E. Ep-CAM-mediated adhesions negatively regulate cadherin-mediated adhesions, affecting epithelial differentiation and growth. Overexpression of Ep-CAM is associated with enhanced epithelial proliferation and is highly expressed in human carcinomas, serving as a marker for tumors of epithelial lineage. It is found on the basolateral surface of most simple epithelia and many carcinoma types and helps distinguish adenocarcinomas from pleural mesotheliomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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