Thermo Fisher Scientific BCAR3 Monoclonal Antibody (3G4)
BCAR3 단백질을 인식하는 Mouse monoclonal antibody (Clone 3G4). Western blot 및 ELISA에 적합. 인간 시료 반응성. Affinity chromatography로 정제된 액상형 비표지 항체. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.03 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3G4 |
| Immunogen | BCAR3 (AAH39895, 266 a.a. ~ 373 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
YGTSPGQARE GSLTKGRPDV AKRLSLTMGG VQAREQNLPR GNLLRNKEKS GSQPACLDHM QDRRALSLKA HQSESYLPIG CKLPPQSSGV DTSPCPNSPV FRTGSEPA
Target Information
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 (BCAR3) was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hallmark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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