Thermo Fisher Scientific BCAR3 Monoclonal Antibody (3G4)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

ELISA (ELISA)

0.03 ng/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

3G4

Immunogen

BCAR3 (AAH39895, 266 a.a. approximately 373 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:BCAR3,uniProtId:O75815-1,ncbiNodeId:9606,antigenRange:266-373,antigenLength:825,antigenImageFileName:H00008412-M01_BCAR3_O75815-1_House_mouse.svg,antigenImageFileNamePDP:H00008412-M01_BCAR3_O75815-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: YGTSPGQARE GSLTKGRPDV AKRLSLTMGG VQAREQNLPR GNLLRNKEKS GSQPACLDHM QDRRALSLKA HQSESYLPIG CKLPPQSSGV DTSPCPNSPV FRTGSEPA

Target Information

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.