Thermo Fisher Scientific RIP1 Polyclonal Antibody
RIP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot에 사용 가능. 인간 및 비인간 영장류 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체이며, -20°C에서 보관. 연구용으로만 사용.
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Thermo Fisher Scientific RIP1 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding arginine 413 of human RIP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.5 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10980567 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage.
Upon activation of TNFR1 by TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor.
Phosphorylates DAB2IP at Ser-728 in a TNF-alpha-dependent manner, activating the MAP3K5-JNK apoptotic cascade.
Ubiquitination by TRAF2 via Lys-63-linked chains enhances communication with downstream transducers in MAPK and NF-kappa-B pathways, leading to activation of inflammatory genes.
Polyubiquitinated RIP1 binds to IKBKG/NEMO, a key step for NF-kappa-B activation.
Interaction with other RHIM-containing adapters initiates gene activation and cell death.
RIPK1 and RIPK3 association forms a necrosis-inducing complex.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-17435_RIP1_Q13546-1_Rabbit.svg, PA5-17435_RIP1_Q13546-1_Rabbit_PDP.jpeg)
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