Thermo Fisher Scientific 4-1BB Ligand Recombinant Rabbit Monoclonal Antibody (014)

Applications and Tested Dilution

Product Specifications

Additional Formats

• APC
• FITC
• PE
• PerCP
• Request custom conjugation

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to avoid contamination.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Improved specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Mouse TNFSF9/4-1BBL.

Target Information

CD137 ligand (CD137L) is a type II membrane protein and member of the TNF superfamily. It acts as a co-stimulatory molecule expressed on antigen-presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on various cells, including inflamed endothelial cells, enhancing monocyte extravasation.

Activated T cells express CD137, and engagement with CD137L promotes:

• T cell proliferation
• IL-2 secretion
• Survival and cytotoxic activity

CD137L is expressed in most B-cell lymphomas (mantle cell, follicular, diffuse large B-cell) and carcinoma cell lines, but absent in Hodgkin and T-cell lymphomas. It is implicated in T cell–tumor cell interactions.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.