Thermo Fisher Scientific COMMD1 Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
FWKSHKTKIR ESLMNQSRWN SGLRGLSWRV DGKSQSRHSA QIHTPVAIIE LELGKYGQES EFLCLEFDEV KVNQILKTLS EVEESISTL

Target Information

Proposed scaffold protein implicated in diverse physiological processes, potentially linked to regulation of ubiquitination of specific cellular proteins.

• Modulates activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1.
• Promotes ubiquitination and proteasomal degradation of NF-κB subunit RELA, down-regulating NF-κB activity.
• Regulates membrane expression and ubiquitination of SLC12A2 and ENaC subunits, affecting Na⁺ transport in epithelial cells.
• Promotes CFTR surface expression and SCNN1D localization to recycling endosomes.
• Involved in copper ion homeostasis and ATP7A trafficking.
• Binds one copper ion per monomer and associates with CCC and WASH complexes on early endosomes.
• Regulates HIF1A-mediated transcription by competing with ARNT/Hif-1β, decreasing DNA binding and transcriptional activation.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.