Thermo Fisher Scientific COMMD1 Polyclonal Antibody
Thermo Fisher Scientific의 COMMD1 Polyclonal Antibody는 인간 COMMD1 단백질을 인식하는 토끼 유래 IgG 항체입니다. 면역세포화학(ICC/IF)에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 단기 4°C, 장기 -20°C 보관이 권장됩니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human COMMD1. Recombinant protein control fragment: Product #RP-106223 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856698 |
Product Specific Information
Immunogen sequence:
FWKSHKTKIR ESLMNQSRWN SGLRGLSWRV DGKSQSRHSA QIHTPVAIIE LELGKYGQES EFLCLEFDEV KVNQILKTLS EVEESISTL
Target Information
Proposed scaffold protein implicated in diverse physiological processes, potentially linked to regulation of ubiquitination of specific cellular proteins.
- Modulates activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1.
- Promotes ubiquitination and proteasomal degradation of NF-κB subunit RELA, down-regulating NF-κB activity.
- Regulates membrane expression and ubiquitination of SLC12A2 and ENaC subunits, affecting Na⁺ transport in epithelial cells.
- Promotes CFTR surface expression and SCNN1D localization to recycling endosomes.
- Involved in copper ion homeostasis and ATP7A trafficking.
- Binds one copper ion per monomer and associates with CCC and WASH complexes on early endosomes.
- Regulates HIF1A-mediated transcription by competing with ARNT/Hif-1β, decreasing DNA binding and transcriptional activation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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