Thermo Fisher Scientific HLA-DR Monoclonal Antibody (CC108), FITC

Thermo Fisher Scientific HLA-DR Monoclonal Antibody (CC108), FITC

Applications

• Flow Cytometry (Flow)

Tested Dilution: Assay-dependent
Publications: - References

Product Specifications

Additional Formats

• Unconjugated: MA5-28488
• PE conjugate: MA5-28487
• Request custom conjugation

Product Specific Information

Mouse anti-Bovine MHC class II DQ antibody, clone CC158 recognizes Bovine MHC Class II DQ.
MHC Class II molecules are expressed on antigen-presenting cells such as dendritic cells, B lymphocytes, monocytes, macrophages, and activated T lymphocytes. Expression can be induced by interferon gamma on other cell types.

Target Information

HLA-DR is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB).

• The alpha chain gene contains 5 exons:
  • Exon 1 encodes the leader peptide
  • Exons 2 and 3 encode extracellular domains
  • Exon 4 encodes the transmembrane domain and cytoplasmic tail
• DRA acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5.
• The beta chain determines peptide binding specificity, with hundreds of DRB1 alleles described.
• HLA-DR is expressed on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.
• DR, DQ, and DP loci encode the major expressed products of the human class II region.
• MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells, playing a critical role in immune response initiation.

HLA and MHC antibodies are essential in Immunopeptidomics for identifying and characterizing neoantigens via high-performance liquid chromatography coupled to tandem mass spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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