Thermo Fisher Scientific ARID1A Polyclonal Antibody
ARID1A 단백질을 검출하는 Thermo Fisher Scientific의 폴리클로날 항체입니다. Western blot에 최적화되어 있으며, 인간 및 생쥐 시료에서 반응합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 완충액에 보존됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
- Western Blot (WB): 1:200–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to internal residues of human AT rich interactive domain 1A (SWI-like) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2636056 |
Product Specific Information
This antibody detects endogenous levels of total ARID1A protein.
Target Information
The ARID1A gene encodes a member of the SWI/SNF family, which includes proteins with helicase and ATPase activities that regulate transcription by altering chromatin structure. The encoded protein is a component of the ATP-dependent chromatin remodeling complex SNF/SWI, essential for activating genes normally repressed by chromatin. It contains two conserved domains:
- A DNA-binding domain that recognizes AT-rich sequences at the beta-globin locus.
- A C-terminal domain that enhances glucocorticoid receptor-dependent transcriptional activation.
The ARID1A protein confers specificity to the SNF/SWI complex and may recruit it to targets via protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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