Thermo Fisher Scientific ARID1A Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:200–1:1,000

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total ARID1A protein.

Target Information

The ARID1A gene encodes a member of the SWI/SNF family, which includes proteins with helicase and ATPase activities that regulate transcription by altering chromatin structure. The encoded protein is a component of the ATP-dependent chromatin remodeling complex SNF/SWI, essential for activating genes normally repressed by chromatin. It contains two conserved domains:

1. A DNA-binding domain that recognizes AT-rich sequences at the beta-globin locus.
2. A C-terminal domain that enhances glucocorticoid receptor-dependent transcriptional activation.

The ARID1A protein confers specificity to the SNF/SWI complex and may recruit it to targets via protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.