Thermo Fisher Scientific CD155 Monoclonal Antibody (2H7CD155), FITC, eBioscience

Thermo Fisher Scientific CD155 Monoclonal Antibody (2H7CD155), FITC, eBioscience

Applications

• Flow Cytometry (Flow)
  Tested dilution: 5 µL (0.25 µg)/test
  View 1 publication

Product Specifications

Available Formats

• APC
• PE
• PE-Cyanine7
• PerCP-eFluor 710
• Super Bright 436
• Request custom conjugation

Product Specific Information

The monoclonal antibody 2H7CD155 recognizes CD155, also known as the poliovirus receptor. CD155 is a member of the immunoglobulin superfamily with four isoforms; only the alpha and delta forms are expressed on the membrane of monocytes, prostate cancer cells, and neurectodermal or monocytic tumor cell lines. CD155 is also present during mid-gastrulation in embryonic development.

CD155 plays roles in:

• Cell adhesion via interaction with vitronectin (ECM component)
• NK cell-mediated tumor killing

Ligands for CD155 include CD226 and CD96. Blocking CD155 is under investigation for therapeutic prevention of poliovirus variants.

Applications Reported: Flow cytometric analysis
Applications Tested: Pre-diluted and validated on U937 cells
Use at 5 µL (0.25 µg) per test (100 µL final volume; 10⁵–10⁸ cells/test recommended).
Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser

Target Information

The gene encoding CD155 produces a transmembrane glycoprotein of the immunoglobulin superfamily.

• External domain: Mediates attachment to vitronectin
• Intracellular domain: Interacts with dynein light chain Tctex-1/DYNLT1
• Function: Serves as the cellular receptor for poliovirus replication
• Found only in primate lineage
• Multiple transcript variants exist

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.

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