Thermo Fisher Scientific ZMYM2 Polyclonal Antibody
ZMYM2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(Paraffin) 분석에 적합합니다. Dog, Human, Non-human primate에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 기반 완충액에 보관하며 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–1 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Non-human primate |
| Published species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 1250–1300 of human Zinc finger 198 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 0.2% gelatin |
| Contains | 0.05% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_1088352 |
Product Specific Information
- This antibody is 94% homologous to mouse, rat, bovine, and chicken samples, and 76% homologous to xenopus.
- Suggested positive control: mouse skeletal muscle lysate.
Target Information
ZNF198 is a ubiquitously expressed nuclear protein whose physiological role is largely unknown. It contains 5 N-terminal zinc finger motifs for protein-protein interactions, a central proline-rich domain, a C-terminal nuclear localization signal (NLS), and an acidic domain.
A reciprocal chromosomal translocation involving ZNF198 and FGFR1 results in the formation of the ZNF198/FGFR1 fusion kinase protein. This fusion protein acts as a constitutively active cytoplasmic tyrosine kinase, regulating STAT transcription factors (STAT1, STAT3, STAT5). It is oncogenic and associated with atypical myeloproliferative disease, peripheral blood eosinophilia, and T-cell leukemia/lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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