Thermo Fisher Scientific RPS6KB1 Monoclonal Antibody (OTI1G4), TrueMAB
인간 RPS6KB1(p70S6K)에 특이적인 Mouse Monoclonal Antibody로 다양한 응용(WB, IHC, ICC, Flow)에 사용 가능. 고순도 Affinity chromatography 정제, Lyophilized 형태로 안정적 보관. 세포 성장 및 단백질 합성 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G4 |
| Immunogen | Full length human recombinant protein of human RPS6KB1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
RPS6KB1 (p70S6K) is a serine/threonine kinase with two non-identical kinase catalytic domains that phosphorylates multiple residues of the S6 ribosomal protein. It is primarily localized in the cytoplasm and plays a crucial role in growth factor-regulated cell proliferation, motility, immune response, and tissue repair. Acting downstream of PI3-kinase, its main physiological target is the S6 ribosomal protein, which mediates upregulation of protein synthesis. Overexpression and DNA amplification of p70 S6 kinase are observed in certain breast cancer cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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