Thermo Fisher Scientific HMGN3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1.0 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  SKPRKTSAKK EPGTKISRGA KGKKEEKQEA GEEGTAPSAN GDTKVEEAQR

• Storage guidance:
  For short term use, store at 2–8°C up to 1 week.
  For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Predicted homology:
  Cow: 93%
  Dog: 93%
  Guinea Pig: 79%
  Horse: 93%
  Human: 100%
  Mouse: 93%
  Pig: 93%
  Rabbit: 100%
  Rat: 93%

Target Information

HMGN3 binds to nucleosomes, regulating chromatin structure and chromatin-dependent processes such as transcription, DNA replication, and DNA repair. It influences insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Additionally, it regulates the expression of the glucose transporter SLC2A2 by binding to its promoter region and recruiting PDX1 and other transcription factors. It also regulates SLC6A9, a glycine transporter in the CNS, by binding to its transcription start site. HMGN3 may also play a role in ocular development and astrocyte function.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.