Thermo Fisher Scientific PCGF1 Polyclonal Antibody
Human PCGF1 단백질을 인식하는 Rabbit Polyclonal 항체. 면역세포염색(ICC/IF)에 적합하며, 항원 친화 크로마토그래피로 정제됨. PBS/글리세롤 완충액 형태의 액상 시약으로, 4°C 단기 보관 및 -20°C 장기 보관 권장. 연구용으로만 사용 가능.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PCGF1. Recombinant protein control fragment (Product # RP-107677) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2791953 |
Product Specific Information
Immunogen sequence:
MASPQGGQIA IAMRLRNQLQ SVYKMDPLRN EEEVRVKIKD LNEHIVCCLC AGYFVDA
Target Information
Component of the Polycomb group (PcG) multiprotein BCOR complex, required to maintain the transcriptionally repressive state of certain genes such as BCL6 and CDKN1A. Acts as a transcriptional repressor potentially linked to the PKC signaling pathway. Represses CDKN1A expression by binding to its promoter in a retinoic acid response element (RARE)-dependent manner. Promotes cell cycle progression and proliferation and may support tumor cell growth by downregulating CDKN1A.
Also part of a PcG PRC1-like complex that mediates chromatin remodeling via monoubiquitination of histone H2A (Lys-119), maintaining heritable gene repression during development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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