Thermo Fisher Scientific Phospho-eIF4A1 (Tyr48) Polyclonal Antibody
Phospho-eIF4A1 (Tyr48) Rabbit Polyclonal Antibody로 인산화된 EIF4A1의 Tyr48 부위를 특이적으로 인식합니다. Western blot에 적합하며, 인간, 마우스, 랫트 시료에 반응합니다. 고순도 정제 및 안정한 PBS/glycerol buffer에 보관됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human EIF4A1 (Accession P60842), corresponding to amino acid residues around phosphorylated Tyr48 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816757 |
Product Specific Information
This antibody detects endogenous levels of EIF4A1 only when phosphorylated at Tyr48.
Target Information
eIF4A2 is a 407-amino-acid ATP-dependent RNA helicase belonging to the DEAD box helicase family. It contains one helicase ATP-binding domain and a helicase C-terminal domain.
eIF4A2, a subunit of the eIF4F complex, acts as a protein-synthesis initiation factor and plays an important role in the binding of mRNA to the 43S pre-initiation complex of ribosomes.
Human eIF4A2 interacts with the NS5B protein of Hepatitis C virus (HCV) and facilitates genomic RNA synthesis by unwinding the secondary structure of the HCV genome. It is ubiquitously expressed in most normal tissues, but in variable amounts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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