Thermo Fisher Scientific TP53INP2 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence: RLQRARQRAE RHALSAKAVQ RQNRARESRP RRSKNQSSFI YQPCQRQFNY
• Storage guidance:
  • Short-term: 2–8°C, up to 1 week
  • Long-term: -20°C in small aliquots to prevent freeze-thaw cycles
• Predicted homology:
  • Cow: 86%
  • Dog: 79%
  • Guinea Pig: 86%
  • Human: 100%
  • Mouse: 79%
  • Rat: 86%

Target Information

TP53INP2 (tumor protein p53 inducible nuclear protein 2), also known as DOR or PINH, is a 220 amino acid nuclear protein expressed in developing murine brain and spinal cord, as well as in the sensory and motor neuron tracts of the peripheral nervous system.
This protein is involved in the autophagy of mammalian cells and translocates from the nucleus to autophagosome structures after activation of autophagy by rapamycin or starvation.
TP53INP2 acts as a scaffold protein necessary for autophagosome development, recruiting LC3 and LC3-related proteins (e.g., GABARAP, GABARAP-like2) to the autophagosome membrane via interaction with TMEM49.
The TP53INP2 gene is located on human chromosome 20, which encodes over 600 genes and represents approximately 2% of the human genome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.