Thermo Fisher Scientific SMC2 Polyclonal Antibody
SMC2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 저장. 인간 단백질에 반응하며 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SMC2. Recombinant protein control fragment (Product #RP-104066) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647618 |
Product Specific Information
Immunogen sequence:
LSRDIGRLKE TYEALLARFP NLRFAYKDPE KNWNRNCVKG LVASLISVKD TSATTALELV AGERLYNVVV DTEVTGKKLL ERGELKRRYT IIPLNKISAR CIAPETLRVA QNLVGPD
Highest antigen sequence identity to the following orthologs:
- Mouse: 87%
- Rat: 91%
Target Information
CAP-E and CAP-C (Chromosome Associated Protein-E & C) are SMC (Structural Maintenance of Chromosome) family members that form a heterodimeric complex required for mitotic chromosome condensation and proper segregation of genetic information during cell division.
hCAP-C/hCAP-E is part of the condensin complex that interacts with phosphorylated Histone H3 to mediate mitotic chromosome condensation.
Distinct distribution patterns during interphase suggest independent behavior of the two complexes, indicating involvement in different aspects of mitotic chromosome organization in human cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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