Thermo Fisher Scientific SMC2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SMC2. Recombinant protein control fragment (Product #RP-104066). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SMC2,uniProtId:O95347-1,ncbiNodeId:9606,antigenRange:485-601,antigenLength:1197,antigenImageFileName:PA5-64459_SMC2_O95347-1_Rabbit.svg,antigenImageFileNamePDP:PA5-64459_SMC2_O95347-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.10 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647618

Product Specific Information

Immunogen sequence: LSRDIGRLKE TYEALLARFP NLRFAYKDPE KNWNRNCVKG LVASLISVKD TSATTALELV AGERLYNVVV DTEVTGKKLL ERGELKRRYT IIPLNKISAR CIAPETLRVA QNLVGPD

Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 91%.

Target Information

CAP-E and CAP-C (Chromosome Associated Protein-E & C) are also SMC (Structural Maintenance of Chromosome) family members that form a heterodimeric complex required for mitotic chromosome condensation to achieve proper segregation of genetic information during subsequent cell division. hCAP-C/hCAP-E is a component of a multiprotein complex called condensin that interacts with phosphorylation of Histone H3 resulting in the mitotic chromosome condensation. The distribution patterns of the two heterodimeric complexes in interphase nucleus indicate independent behavior of the two complexes during cell cycle. These results suggest that the two distinct complexes are involved in different aspects of mitotic chromosome organization in humar cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.