Thermo Fisher Scientific NLRP3 Polyclonal Antibody
NLRP3 단백질을 인식하는 Thermo Fisher Scientific의 염소 폴리클로날 항체. Western blot 및 IHC(P) 응용에 적합하며, 모든 보고된 isoform을 인식함. 0.5 mg/mL 농도의 액상 항체로 -20°C에서 보관.
- 카탈로그번호
- PA5142555
- 판매단위
- pk
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Thermo Fisher Scientific NLRP3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.3–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence RDLYEKAKRDEPK-C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933202 |
Product Specific Information
- Expected to recognize all reported isoforms (NP_004886.3; NP_899632.1; NP_001120933.1; NP_001120934.1)
- Tested in Peptide ELISA: antibody detection limit dilution 1:32,000
Target Information
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif. It interacts with the apoptosis-associated speck-like protein PYCARD/ASC, a member of the NALP3 inflammasome complex. This complex activates NF-kappaB signaling and regulates inflammation, immune response, and apoptosis. Mutations are associated with familial cold autoinflammatory syndrome and neonatal-onset multisystem inflammatory disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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