Thermo Fisher Scientific HDAC4 Polyclonal Antibody
HDAC4 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 ChIP에 적합하며, 인간 HDAC4에 특이적으로 반응. 고순도 항원 친화 크로마토그래피로 정제된 액상 항체로 안정적인 신호 제공.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20 | - |
| ChIP assay (ChIP) | 1–3 µL | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues M(1)SSQSHPDGLSGRDQPVE(18) of human HDAC4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2118739 |
Product Specific Information
PA1-863 detects histone deacetylase 4 (HDAC4) from human cells.
It has been successfully used in Western blot and ChIP procedures.
By Western blot, this antibody detects an ~140 kDa protein representing HDAC4 from HeLa cell lysate.
An ~110 kDa band may represent a degradation product.
The immunogen is a synthetic peptide corresponding to residues M(1)SSQSHPDGLSGRDQPVE(18) of human HDAC4.
PA1-863 can be used with blocking peptides PEP-141 and PEP-095.
Target Information
Histone deacetylase 4 (HDAC4) deacetylates lysine residues on core histones (H2A, H2B, H3, and H4), contributing to epigenetic repression.
It plays an important role in transcriptional regulation, cell cycle progression, and development.
HDAC4 interacts with myocyte enhancer factors (MEF2A, MEF2C, MEF2D) in muscle maturation and is involved in MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Mutations in the HDAC4 gene are associated with Brachydactyly-mental retardation syndrome (BDMR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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