Thermo Fisher Scientific CALHM1 Polyclonal Antibody, Atto 594

Thermo Fisher Scientific CALHM1 Polyclonal Antibody, Atto 594

Applications

• Immunohistochemistry (Frozen) (IHC(F)): 1:200

Product Specifications

Product Specific Information

• Reconstitution: Add 50 µL double distilled water (DDW) depending on sample size.
• Ships as lyophilized powder at room temperature; store at -20°C upon arrival.
• Reconstituted solution can be stored at 4°C for up to 1 week.
• For long-term storage, aliquot and keep at -20°C.
• Avoid multiple freeze/thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by neuronal loss and senile plaques composed of aggregated amyloid-beta (Aβ) peptides produced by endoproteolysis of the amyloid precursor protein (APP).
CALHM1 (Calcium Homeostasis Modulator 1) is a multipass transmembrane glycoprotein that regulates cytosolic Ca²⁺ concentration and Aβ levels.
Studies suggest CALHM1 may influence AD risk by modulating Ca²⁺-dependent proteolysis of APP through control of intracellular calcium levels.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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