Thermo Fisher Scientific MARCH1 Polyclonal Antibody
Human MARCH1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 용액 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장. 연구용 전용 제품.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: Not specified
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MARCH1. Recombinant protein control fragment (Product # RP-90986) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2643761 |
Product Specific Information
Immunogen sequence:
KVYVQLWRRL KAYNRVIFVQ NCPDTAKKLE KNFSCNVNTD IKDAVVVPVP QTGANSLPSA EGG
Highest antigen sequence identity to orthologs:
- Mouse: 89%
- Rat: 87%
Target Information
E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS, and MHC class II proteins (e.g., HLA-DR alpha and beta), promoting their endocytosis and lysosomal sorting via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, it down-regulates their surface localization and retains them within the intracellular endosomal system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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